Remodulating the Nervous System to Restore the Human Functioning
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The primary goal of Villa Beretta Rehabilitation Research Innovation Institute’s research activities is to develop clinical treatments aimed at restoring human functioning after disabilities caused by injuries and diseases affecting the Central Nervous System (CNS). The research and innovation activities are embedded within and materialize through the scientific framework of Network and Systems Medicine.
This field, recognized for its complexity, integrates various disciplines, including medicine, biology, neuropsychology, nutritional science, bioengineering, social sciences, and the humanities in Rehabilitation Medicine. These disciplines are combined and coordinated in an interdisciplinary manner, providing an overarching view of interconnected biological and social systems that influence human functioning.
This leads to a precise strategy of continually seeking new technologies capable of interacting with individuals to remodulate the connections of complex systems, particularly the nervous system, which is crucial for human functioning. This functioning translates into individuals’ ability to act and interact with their environment, manifesting behaviors that shape their identity in accordance with their health status.
Our strategy is based on an innovative bio-tech approach and focuses on the biological principles of neuroplasticity, which is the ability of the nervous system to reorganize itself and form new functional neural connections.
When appropriately stimulated, the nervous system reorganizes itself through an increase in synaptic plasticity and functional connectivity. This is also attributed to the heightened activity of neurotransmitters, which are considered the fuel for its operation. All these factors, when combined, further stimulate cerebral reorganization, supporting and strengthening the recovery of the ability to think, move, and relate flexibly with the surrounding environment.
Equal importance is placed on the biological mechanisms that regulate the gut-brain axis, the two-way communication between the enteric nervous system (the gut) and the central nervous system (the brain). Research is demonstrating that this connection is increasingly important in regulating motor and cognitive functions, as well as metabolism and immune response.
